KLF4 Antikörper (C-Term)

Produktnummer ABIN2780577

Dieser Kaninchen Polyklonal Antikörper erkennt spezifisch KLF4 in WB und IHC. Er zeigt eine Reaktivität gegenüber Human, Maus, Ratte, Rind (Kuh), Pferd, Hund, Kaninchen, Meerschweinchen und Zebrafisch (Danio rerio) und wurde in 1 Publikation erwähnt.

Kurzübersicht für KLF4 Antikörper (C-Term) (ABIN2780577)

Target: KLF4 (Kruppel-Like Factor 4 (Gut) (KLF4))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Pferd, Hund, Kaninchen, Meerschweinchen, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KLF4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-KLF4 Antikörper

Bindungsspezifität: C-Term

Sequenz: AGCGKTYTKS SHLKAHLRTH TGEKPYHCDW DGCGWKFARS DELTRHYRKH

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against KLF4. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human KLF4

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 470 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-KLF4 Antikörper (ABIN2780577)

Natesampillai, Kerkvliet, Leung, Veldhuis: "Regulation of Kruppel-like factor 4, 9, and 13 genes and the steroidogenic genes LDLR, StAR, and CYP11A in ovarian granulosa cells." in: American journal of physiology. Endocrinology and metabolism, Vol. 294, Issue 2, pp. E385-91, (2008) (PubMed).

Details zu KLF4

Target: KLF4 (Kruppel-Like Factor 4 (Gut) (KLF4))

Andere Bezeichnung: KLF4

Hintergrund: The mammalian Kruppel-like transcription factor, KLF4 is involved in preventing centrosome amplification following DNA damage caused by gamma-irradiation. It is both necessary and sufficient in preventing centrosome amplification following gamma-radiation-induced DNA damage and does so by transcriptionally suppressing cyclin E expression n. Kruppel-like factor 4 is also known to exhibit checkpoint function during the G1/S and G2/M transitions of the cell cycle.
Alias Symbols: EZF, GKLF
Protein Interaction Partner: EP300, CREBBP, SETD7, CTBP1, Dlg4, APP, CUL2, VHL, UBC, TCEB2, SP1, RELA, PRKCD, PPARG, SMARCA4, HDAC2, HDAC7, KAT5, HDAC1, HDAC5, ELK1, KLF6, TP53,
Protein Size: 470

Molekulargewicht: 50 kDa

Gen-ID: 9314

NCBI Accession: NM_004235, NP_004226

UniProt: O43474

Pathways: Peptide Hormone Metabolism, Stem Cell Maintenance